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Anlet Plus 1 Strip
Aspirin 75 mg + Clopidogrel 75 mg Tablet
Clopidogrel:
- A prodrug that requires metabolic activation to exert its effects.
- It works by irreversibly binding to P2Y12 receptors on platelets, preventing platelet activation and aggregation.
- The antiplatelet effect starts within 2 hours of a single dose, with peak activity achieved between days 3 and 7 of regular dosing (75 mg daily).
Aspirin:
- It irreversibly inhibits platelet cyclooxygenase (COX) enzymes, blocking thromboxane A2 synthesis. This action reduces platelet aggregation and vasoconstriction.
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✅ Description:
Anlet Plus-
Acute Coronary Syndrome (ACS)
Anlet PLUS is prescribed to lower the risk of heart attack (myocardial infarction) and stroke in patients diagnosed with:
- Non-ST-segment elevation ACS: Includes unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI).
- Acute ST-segment elevation ACS: Also known as ST-elevation myocardial infarction (STEMI).
In individuals with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease, Anlet PLUS helps reduce the likelihood of recurrent MI or stroke.
Note: Always consult a registered medical professional before taking this medication.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects of Anlet Plus
- Abdominal pain, diarrhea, bruising, nosebleeds, and gastrointestinal bleeding.
- Thrombotic thrombocytopenic purpura (TTP), which requires immediate medical attention.
✔️ Pharmacokinetics
- Absorption: Clopidogrel is rapidly absorbed, with at least 50% bioavailability. Peak plasma concentrations of the main circulating metabolite occur approximately 1 hour after a 75 mg dose.
- Metabolism: Clopidogrel undergoes rapid hepatic metabolism, primarily converting into an inactive carboxylic acid derivative, which constitutes 85% of circulating drug-related compounds.
- Excretion: The drug is excreted in both urine (50%) and feces (46%) over five days. Its active metabolite has a half-life of 8 hours.
- Protein Binding: Both Clopidogrel and its metabolite bind to plasma proteins (>90%).
- Food Effect: Food intake does not significantly alter Clopidogrel’s bioavailability.
✔️ Overdose Management
- Clopidogrel: Overdose may lead to excessive bleeding. Platelet transfusion might help restore clotting function.
- Aspirin: Symptoms range from dizziness and nausea to severe complications like respiratory or metabolic acidosis. Treatment includes gastric lavage, supportive care, and, if necessary, hemodialysis.
✔️ Quick Suggestions:
- Take Anlet PLUS regularly, at the same time each day, with food to minimize stomach upset.
- Avoid activities that increase the risk of bleeding, such as shaving with razors or using sharp objects.
- Inform your doctor before any surgery or dental procedures.
- Maintain a healthy lifestyle, including a low-fat diet and regular exercise, to maximize treatment benefits.
✔️ Dosage and Administration of Anlet Plus
- General Dosing: 75 mg once daily, with or without food.
- ACS Treatment: Start with a loading dose of 300 mg, followed by 75 mg daily. Aspirin (75-325 mg daily) should be co-administered.
- Elderly and Renal Patients: No dosage adjustment is needed.
✔️ Pregnancy:
- Use during the first two trimesters only if necessary. Avoid during the third trimester.
✔️ Lactation:
- Clopidogrel’s excretion in breast milk is unknown, but Aspirin is excreted; discontinue during breastfeeding.
✔️ Children:
- Not recommended for those under 12 years due to the risk of Reye's syndrome, particularly in viral illnesses like influenza or chickenpox.
✔️ Drug Interactions
- Aspirin: Enhances Clopidogrel's effect without altering its platelet inhibition mechanism.
- NSAIDs: Increased risk of gastrointestinal (GI) bleeding. Use with caution.
- Heparin: No dosage adjustment is required, but co-administration should be monitored.
- Warfarin: Combining Clopidogrel with Warfarin raises bleeding risk and should be done with caution.
✔️ Do not use Anlet PLUS in the following situations:
- Hypersensitivity to Aspirin, Clopidogrel, or other components.
- Active bleeding, such as from peptic ulcers or intracranial hemorrhage.
✔️ Precautions and Warnings
- Bleeding Risk: Anlet PLUS prolongs bleeding time, so exercise caution during surgery or in conditions with high bleeding risks.
- Reye’s Syndrome: Aspirin use in children can lead to Reye’s syndrome, a potentially fatal condition.
- Liver and Kidney Impairment: Avoid use in severe hepatic impairment or renal dysfunction.
✔️ Storage
- Store in a cool, dry place below 30°C, protected from light and moisture.
- Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
